Collaborate 2 Cure
July 10, 2017

 

Location: Please note location change for July 10

Enterprise Center of Johnson County (ECJC)
4220 Shawnee Mission Parkway, Suite 350B, Fairway, KS 66205

Can’t join us in person? Join virtually using Zoom! 
Please register to attend and select “Virtually by Zoom” and the link will be in your registration confirmation email.

TDP-43 Mitochondrial Localization and Possible TSPO Involvement in Neurodegeneration

TDP-43 is a small (43 kDa) ubiquitously expressed RNA-and DNA-binding protein. It primarily binds mRNA and regulates post-transcriptional RNA processing, including RNA splicing, transportation and translation. The mislocalization of TDP-43 to the cytoplasm represents a key pathological feature of major neurodegenerative diseases. Recent studies have revealed that TDP-43 accumulation in mitochondria is linked in neuronal death. How does TDP-43 gets into mitochondria is not well known. One possible transporter named TSPO (18 kDa) may be involved in the transportation of TDP-43. Our preliminary work suggests that TDP-43 and TSPO may be co-exist in mitochondria.

Speaker- A. “Baki “Agbas, MSc,PhD

Dr. Agbas earned his doctoral degree from University of Szeged (formerly Attila Josef Science University) in Szeged, Hungary, and completed post-doctoral training at the University of Kansas Medical Center. He then joined to Department of Pharmacology & Toxicology/Higuchi Biosciences Center at KU-Lawrence campus as Research Assistant Professor. He joined to KCU in 2010 as an associate professor.

Dr.Agbas’ research interests include a focus on the molecular biology of aging and aging related neurodegenerative diseases. He was a co-leader of National Institute of Aging supported program project in the field of the Reactive Oxygen Species and Aging for more than a decade. Dr. Agbas’ specifically studied glutamate, neurotransmission, aging, longevity and neurite remodeling. He has published research on key proteins (such as Calcineurin and glutamate binding proteins) in the central nervous system that undergoes oxidative modifications during brain aging. While at KCU, Dr.Agbas has shifted his research interest to study neuronal bioenergetics system (i.e. Plasma membrane Redox System and Mitochondria) in aging and neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) in particular. He is also studying Zinc homeostasis in mitochondria of ALS model mice and Planning to extend his studies to zebra fish as a proposed animal model for ALS related studies.

Role of NAMPT in Mitochondrial Energy Metabolism and Function in Neurons

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD+ salvage pathway in mammals and it is mainly expressed in neurons in the mouse brain. The presentation will discuss our recent findings of NAMPT in brain ischemia and mitochondrial function.

Speaker: Shinghua Ding, PhD

Shinghua Ding received his PhD from the Dept. of Biological and Chemical Engineering at State University of New York-Buffalo. He is currently an associate professor in Dept. of Bioengineering and an investigator in Dalton Cardiovascular Research Center at University of Missouri-Columbia. His research has been focusing on the mechanisms of brain protection after focal ischemia stroke using photothrombosis –induced mouse ischemic model.