KU Clinical Research: Fairway Auditorium
4350 Shawnee Mission Parkway Fairway, KS 66205
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Diabetic Peripheral Neuropathy and Response to Exercise and Activity
Diabetic peripheral neuropathy (DPN) occurs in more than 50% of people with diabetes and is an important risk factor for skin breakdown, amputation, and reduced physical mobility. The presence of hyperglycemia, obesity, and dyslipidemia trigger mitochondrial dysfunction and metabolic dysregulation. Although there are no proven pharmacologic approaches to reduce DPN risk or slow its progression, evidence suggests that physical activity may improve symptoms and enhance peripheral nerve regeneration in animal models and early clinical trials. Although many beneficial effects of exercise for people with diabetes have been well established, few studies have examined whether exercise provides comparable benefits to people with DPN. The Activity for Diabetic Polyneuropathy (ADAPT) study is an ongoing two-site single-blinded randomized controlled trial to determine the effect of exercise on intra-epidermal nerve fiber density and quality of life in people with DPN.
Speaker- Patricia Kluding, PT, PhD
Patricia Kluding, PT, Ph.D. is Professor and Chair of the Department of Physical Therapy and Rehabilitation Sciences. She has been a physical therapist since 1992 with a clinical practice focus in neurological rehabilitation. Kluding has received recognition for her skills as an educator, including the Stata Norton Distinguished Teaching Award for the School of Health Professions (2010). Kluding directs the Health, Exercise, and Aging Lab (HEAL) on clinical research programs focused on improving the health and wellness of people with chronic disease or disability. She has published over 35 manuscripts in peer-reviewed journals, has received internal and external research support, and serves as the primary mentor for several doctoral students working on dissertation research in the rehabilitation science program. She also currently serves as associate director of the Clinical and Translational Science Unit and is responsible for the Frontiers and Pioneers research participant registry programs.
Speaker: Mamatha Pasoor, MD
Dr. Pasnoor is certified by the American Board of Psychiatry and Neurology, American Board of Neuromuscular Medicine and American Board of Clinical Neurophysiology. She also serves as co-director of the University of Kansas Neuropathy Center, along with Dr. Mazen Dimachkie, associate program director for the Neurology Residency Program and associate program director for Neurophysiology and Neuromuscular Medicine. Dr Pasnoor’s practice focuses on neuromuscular diseases and general neurology. Dr. Pasnoor has published in areas of peripheral neuropathies, myasthenia gravis, motor neuron disease and myopathies. She is actively involved in several clinical research programs including diabetic and other neuropathies, myasthenia gravis, myopathies and motor neuron diseases.