Immune Monitoring Toolkit for Canine Immunotherapy Trials
Immunotherapy for cancer has once again become a focus of broad interest in the oncology research community. Recent advances in checkpoint inhibitor therapies have re-kindled interest in specific and non-specific immunotherapy approaches for cancers. The availability of rapid next-generation sequencing has made personalized neoepitope discovery possible. Naturally-occurring cancers in companion animals offer a true-disease model for studying immunotherapy approaches. The intact but cancer-modified immune system of these animals is a near-ideal environment in which to test novel therapeutic approaches. To fully evaluate the systemic and local effects of immunotherapy, a complete understanding of the innate and adaptive responses to intervention is necessary. This lecture will discuss the opportunities, challenges, and current toolbox of immunologic evaluations available in companion animals with cancer.
Jeffrey N. Bryan, DVM, MS, PhD, DACVIM
Hans Rindt, PhD
Sandra (Axiak) Bechtel, DVM, DACVIM-Oncology
Dr. Jeffrey Bryan earned a Bachelor of Science degree in veterinary science from the University of California – Davis in 1991. He received his D.V.M. from the University of California – Davis in 1993. He then worked as an Associate Veterinarian from 1993-1995, and then served as Medical Director of the Irving Street Veterinary Hospital in San Francisco, CA from 1995-2002. Bryan completed a medical oncology residency, a Masters of Biomedical Sciences, and a PhD in Pathobiology at the University of Missouri. He received certification by the American College of Veterinary Internal Medicine in Oncology 2005. He has been a research assistant professor at the University of Missouri and an assistant professor of Oncology at Washington State University prior to his current position of associate professor at the University of Missouri. Dr. Bryan is the director of the Comparative Oncology Radiobiology and Epigenetics Laboratory as well as the Tom and Betty Scott Endowed Program in Veterinary Oncology at the University of Missouri. He is the past president of the American College of Veterinary Internal Medicine Oncology Specialty. His particular areas of research interest are epigenetics of cancer and targeted cancer imaging and therapy. He is committed to advancing true-disease models of cancer for more rapid translation of advances.
Dr. Hans Rindt received a Master of Science degree in biological sciences in 1986 from the University of Karlsruhe, Germany. His graduate work at the Max Planck Institute for Biomedical Research was on the development and characterization of muscle cell lines for the study of Duchenne’s muscular dystrophy which earned him a Ph.D. from the University of Heidelberg in 1989. Following a postdoctoral fellowship at the Children’s Hospital Research Foundation in Cincinnati, Rindt has worked both in industry and academia for a number of years. He is currently Senior Research Associate at the Veterinary Health Center, University of Missouri where he manages the research activities of the Comparative Internal Medicine Laboratory. He also serves as a liaison to the Comparative Oncology Radiobiology and Epigenetics Laboratory at the University of Missouri.
Dr. Sandra (Axiak) Bechtel graduated from Michigan State University’s College of Veterinary Medicine, then completed an internship at Mississippi State University followed by a residency in medical oncology at Gulf Coast Veterinary Specialists in Houston. She achieved board certification in veterinary oncology through the American College of Veterinary Internal Medicine and practiced at Veterinary Specialists of North Texas in Dallas prior to joining the University of Missouri in 2009. She is currently an associate professor at the University of Missouri and her professional interests include clinical translation of new cancer therapies, immunodysfunction and immunomodulation in cancer treatment and nanotherapeutics.
Kauffman Foundation Conference Center
4801 Rockhill Rd, Kansas City, MO 64110
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